Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya
Takatsugu Okai, Chim W Chan, Achyut KC, Protus Omondi, Kelvin Musyoka, James Kongere, Wataru Kagaya, Gordon Okomo, Bernard N Kanoi, Yasutoshi Kido, Jesse Gitaka, Akira Kaneko · 2024
Read Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya by Takatsugu Okai, Chim W Chan, Achyut KC, Protus Omondi, Kelvin Musyoka, James Kongere, Wataru Kagaya, Gordon Okomo, Bernard N Kanoi, Yasutoshi Kido, Jesse Gitaka, Akira Kaneko (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11653864.txt.
Description
Malaria rapid tests look for a parasite protein, and some parasites have deleted the gene for it, turning invisible. Takatsugu Okai and eleven co-authors hunted those stealth strains around Lake Victoria, Kenya, in a 2024 study. Four surveys gathered over 9,000 finger-prick samples, each tested by the rapid test, microscopy, and DNA methods.
Samples the rapid test missed but DNA confirmed were checked for quality, then screened for deletions in the two related genes, pfhrp2 and pfhrp3. The team also counted how many parasite strains each person carried and modeled which factors tracked with deletion. The work matters for policy: where deleted strains spread, the standard cheap test silently undercounts malaria. Mapping them tells programs when to switch diagnostics before control efforts are misled by reassuring, wrong numbers.
Catalog record
| CREATOR | Takatsugu Okai, Chim W Chan, Achyut KC, Protus Omondi, Kelvin Musyoka, James Kongere, Wataru Kagaya, Gordon Okomo, Bernard N Kanoi, Yasutoshi Kido, Jesse Gitaka, Akira Kaneko |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |