Factors influencing Nirmatrelvir/Ritonavir concentration in patients with COVID-19
Ping Xu, Lijun Zhang, Qingguo Wu · 2024
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Description
Ping Xu, Lijun Zhang, and Qingguo Wu asked why a COVID drug pair often misses its target blood level, in a study published in 2024. The pair works when its low point stays above a set mark. The team read drug levels from 114 adult patients in mid 2022 and split them by that mark. Background facts and blood readings were weighed for links.
Kidney clearance rate stood out: as it rose, drug levels fell. Height, weight, a nutritional health score, and one cell count also stood as independent drivers. Food state, in fact, was a key the team flags for dose care. Once body mass calculations were applied, bulk alone lost its link. The authors urge level checks for fast or slow kidneys, and dose changes for poorly fed patients.
Catalog record
| CREATOR | Ping Xu, Lijun Zhang, Qingguo Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |