Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex
Xueyu Guo, Trevor Lee, Jason Sun, Julianne Sun, Wenjie Cai, Qingwei Yang, Tao Sun · 2024
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Description
Some of the first neurons born in the developing human brain are subplate neurons, which wire the cortex while it is still being built. Xueyu Guo and co-authors chart where these cells come from and where they settle, using spatial gene mapping and single-cell sequencing of fetal cortex from weeks ten to twenty-five of gestation.
Genes tied to the cells' support scaffolding stay prominent in subplate neurons across regions, with the richest expression in the frontal lobe. Human-specific genes also hold a steady share in this population. The maps reveal the cells' molecular origins and lineage paths as the cortex folds and layers. The authors present the work as a foundation for understanding how the earliest cortical wiring is laid down, and how its disruption might echo in later brain disorders.
Catalog record
| CREATOR | Xueyu Guo, Trevor Lee, Jason Sun, Julianne Sun, Wenjie Cai, Qingwei Yang, Tao Sun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |