IIIVmrMLM.QEI: An effective tool for indirect detection of QTN-by-environment interactions in genome-wide association studies
Ya-Wen Zhang, Xue-Lian Han, Mei Li, Ying Chen, Yuan-Ming Zhang · 2024
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Description
Ya-Wen Zhang and co-authors introduce, in a 2024 genetics paper, a software tool that finds genes whose effects change with the environment. Such gene-by-environment links matter for traits like flowering time, but past tools were not both flexible and accurate. The new tool builds on a mixed-model method for genome-wide association studies.
Simulations showed the new fixed-effect form had more power than two older methods. In a fresh look at flowering time in a small model plant across three heat levels, the tool found more known links than older methods. All of its top finds were backed by checks on gene variants and by past work linking them to heat.
Catalog record
| CREATOR | Ya-Wen Zhang, Xue-Lian Han, Mei Li, Ying Chen, Yuan-Ming Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |