Exploring the Anxiolytic Potential of NPY by a Dipeptidyl Peptidase-IV Inhibitor in an Animal Model of PTSD
Matan Dahan, Joseph Zohar, Doron Todder, Aleksander A Mathé, Hagit Cohen · 2024
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Description
Matan Dahan and co-authors test a drug's effect on stress responses in rats. Their 2024 paper centers on a brain peptide called NPY, which can calm anxiety. An enzyme cuts that peptide and changes what it does. The drug sitagliptin blocks that enzyme, so it could raise the peptide's calming form.
Rats were exposed to a predator scent, a model for post-traumatic stress. Some got the drug once soon after, others over three days, at varied doses. A week later, maze and startle tests showed no drop in anxiety-like behavior versus salt water. The high dose did raise peptide levels in several brain areas. But receptor levels did not change. The authors say raising the peptide alone is not enough.
Catalog record
| CREATOR | Matan Dahan, Joseph Zohar, Doron Todder, Aleksander A Mathé, Hagit Cohen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |