Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells
Meshal A Alobaid, Sarah-Jane Richards, Morgan R Alexander, Matthew I Gibson, Amir M Ghaemmaghami · 2024
Read Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells by Meshal A Alobaid, Sarah-Jane Richards, Morgan R Alexander, Matthew I Gibson, Amir M Ghaemmaghami (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11652954.txt.
Description
Five authors, led by Meshal Alobaid, studied how sugar coatings steer gold nanoparticles inside dendritic cells in this 2024 paper. Dendritic cells start the adaptive immune response, so they are a prime target for drug delivery and immune tuning. Gold particles are a favored delivery platform since they are gentle on cells and easy to shape.
The team coated 16-nanometer gold spheres with 30 unique blends of simple sugars, using mannose, galactose, and fucose in varied shares. They then tracked how the coatings changed cell uptake and where the particles traveled inside the cells. Particles coated fully with fucose or fully with mannose were taken up well. Two mannose-rich blends also entered cells at high rates. The results show that the sugar coat acts like an address label, guiding where a particle ends up.
Catalog record
| CREATOR | Meshal A Alobaid, Sarah-Jane Richards, Morgan R Alexander, Matthew I Gibson, Amir M Ghaemmaghami |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |