Identification of potential biomarkers from amino acid transporter in the activation of hepatic stellate cells via bioinformatics
Yingying Zhao, Xueqing Xu, Huaiyang Cai, Wenhong Wu, Yingwei Wang, Cheng Huang, Heping Qin, Shuangyang Mo · 2024
Read Identification of potential biomarkers from amino acid transporter in the activation of hepatic stellate cells via bioinformatics by Yingying Zhao, Xueqing Xu, Huaiyang Cai, Wenhong Wu, Yingwei Wang, Cheng Huang, Heping Qin, Shuangyang Mo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11652522.txt.
Description
Yingying Zhao and co-authors mine data for markers of liver scarring in a 2024 study. Scarring starts when stellate cells in the liver wake up and lay down fibers. Amino acid transporters, which feed cell growth, may take part, but their role was murky.
The team used two public gene data sets of woken stellate cells. Fifteen transport genes differed between woken and resting cells. Network maps and two learning methods cut the list to two genes, SLC7A5 and SLC1A5. Both held up in the check data set. Further maps tied the pair to growth paths, drug links, and scar markers like collagen. The pair may serve as early signs, or even targets, in liver fibrosis care.
Catalog record
| CREATOR | Yingying Zhao, Xueqing Xu, Huaiyang Cai, Wenhong Wu, Yingwei Wang, Cheng Huang, Heping Qin, Shuangyang Mo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |