Zhuanggu Shubi ointment mediated the characteristic bacteria-intestinal mucosal barrier-bone metabolism axis to intervene in postmenopausal osteoporosis
Xiaoya Li, Ning Li, Huan Pei, Yu Ren, Lei Li, Lan Sun, Yueying Wu, Jiali Yuan, Yuan Ma · 2024
Read Zhuanggu Shubi ointment mediated the characteristic bacteria-intestinal mucosal barrier-bone metabolism axis to intervene in postmenopausal osteoporosis by Xiaoya Li, Ning Li, Huan Pei, Yu Ren, Lei Li, Lan Sun, Yueying Wu, Jiali Yuan, Yuan Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11652507.txt.
Description
Xiaoya Li and co-authors study, in a 2024 paper, how a traditional ointment fights bone loss after menopause by way of the gut. The ointment is known to help women with this form of osteoporosis, but its route through gut microbes and the intestinal wall was unmapped. The team built the condition in rats by removing the ovaries, then treated them with the ointment and watched bones, gut bacteria, and gut lining together.
Treatment raised markers of bone building and lowered markers of bone breakdown, and the thigh bone improved. In the colon, the seal proteins of the gut wall rose, alarm signals fell, and two bacterial groups grew more common. Those bacteria tracked with a stronger gut wall and calmer inflammation. The authors conclude that the ointment works along a bacteria, gut wall, and bone axis, easing the disease from the intestine outward.
Catalog record
| CREATOR | Xiaoya Li, Ning Li, Huan Pei, Yu Ren, Lei Li, Lan Sun, Yueying Wu, Jiali Yuan, Yuan Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |