The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies
Youtian Zhang, Jian Wang, Hongchao Yang, Yong Guan · 2024
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Description
Youtian Zhang and three co-authors review in 2024 how a common group of chemicals in plastics may cause a birth defect of the penis in males. In hypospadias, the urinary opening forms in the wrong place. Exposure of a mother to these chemicals, called phthalates, during pregnancy is a known risk, and rodent studies let teams trace how the harm unfolds.
From 326 papers, twenty-two fit the review. Their findings fell into five paths, led by disruption of sex hormone signals, with cell change, self-eating, cell death, and blood vessel growth also in play. A stress agent in cells linked the paths. The authors see hormone disruption as the likely first step.
Catalog record
| CREATOR | Youtian Zhang, Jian Wang, Hongchao Yang, Yong Guan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |