What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?
Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, Eckhard Wolf · 2024
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Description
Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, and Eckhard Wolf asked in 2024 which gene changes in source pigs are truly needed for xenotransplantation. Pigs can supply cells, tissues, and organs for people, but the grafts must be shielded from immune attack and from clotting problems.
Gene tools now allow many knockouts and added protective genes at once, yet each extra unit makes breeding the pigs harder. The authors weigh which changes have worked best for heart, kidney, and islet grafts, and why breed choice matters. They also discuss deep checks of pig organs placed in human decedents, plus gene knockdown during organ perfusion, as ways to pick the smallest set that works.
Catalog record
| CREATOR | Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, Eckhard Wolf |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |