Prognostic significance of B cell senescence-associated genes as risk markers in prostate adenocarcinoma
Huaiying Zheng, Wei Jiang, Shaoxing Zhu, Xiaobao Chen · 2024
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Description
Huaiying Zheng, Wei Jiang, Shaoxing Zhu, and Xiaobao Chen build in 2024 a risk score for prostate cancer from genes tied to aging B cells. Prostate adenocarcinoma is common in men, and targeted treatment is hard, so better forecasts of outcome are valuable. The team mined large public cancer data sets for genes that both differ in tumors and relate to B cell aging.
Three genes passed their screens and formed the score. Patients split by the score showed clearly different survival, and the model held up on standard accuracy curves. High-risk tumors carried more immune cell traffic and more mutations in two well known cancer genes. They also resisted several drugs more strongly. A chart combining the score with clinical traits predicted individual outlook reliably. The authors offer the model as a reference for guiding care in this cancer.
Catalog record
| CREATOR | Huaiying Zheng, Wei Jiang, Shaoxing Zhu, Xiaobao Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |