Targeting C797S mutations and beyond in non-small cell lung cancer—a mini-review
Wolfram C. M. Dempke, Klaus Fenchel · 2024
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Description
Wolfram Dempke and Klaus Fenchel review next generation drugs for resistant lung cancer mutations in a 2024 paper. Lung cancers of the non small cell type often carry growth receptor mutations that targeted pills exploit well. Tumors escape the best current pill through a further mutation, C797S, which blocks it. Fourth generation inhibitors aim to beat that escape route.
One oral candidate is mutation selective, enters the brain, and cannot be undone by the tumor target. It beat resistance in lab models and showed early promise in patients carrying the escape mutation, with trials running. The review also covers rarer mutations and what lies beyond the current drug wave.
Catalog record
| CREATOR | Wolfram C. M. Dempke, Klaus Fenchel |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |