Evolution of two metabolic genes involved in nucleotide and amino acid metabolism in Pseudomonas aeruginosa
Yutong Wu, Yuqi Shi, Xiaohui Liang, Rajesh P. Shastry, Rajesh P. Shastry, Rajesh P. Shastry · 2024
Read Evolution of two metabolic genes involved in nucleotide and amino acid metabolism in Pseudomonas aeruginosa by Yutong Wu, Yuqi Shi, Xiaohui Liang, Rajesh P. Shastry, Rajesh P. Shastry, Rajesh P. Shastry (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11651626.txt.
Description
Yutong Wu, Yuqi Shi, and Xiaohui Liang (2024) traced the history of two metabolic genes in Pseudomonas aeruginosa. The bacterium causes hard-to-treat infections. The genes make a guanine-breaking enzyme and a transporter that imports branched-chain amino acids, both feeding the cell's building-block supply. The team searched the species' population and found each gene exists in two copies, then rebuilt the family tree of each copy to see where it came from.
One copy of each gene descends from the ancestor of the wider Pseudomonas group. The second copies arrived later in the ancestors of this species. The copy pairs have drifted apart: they evolve at different rates, switch on at different levels, and partner with different gene networks, some tied to infecting hosts, biofilms, and drug resistance. The authors argue this doubling and splitting widened the bacterium's metabolic range in hospital settings.
Catalog record
| CREATOR | Yutong Wu, Yuqi Shi, Xiaohui Liang, Rajesh P. Shastry, Rajesh P. Shastry, Rajesh P. Shastry |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |