Colonic dysmotility regulated by downregulation of PDGFRα+ cells / SK3 channel in DSS-induced colitis mice
Chen Lu, Hongxia Zhu, Haiqian Lu, Xianjing Xie, Ling Tong, Yujia Li, Zhida Qian · 2024
Read Colonic dysmotility regulated by downregulation of PDGFRα+ cells / SK3 channel in DSS-induced colitis mice by Chen Lu, Hongxia Zhu, Haiqian Lu, Xianjing Xie, Ling Tong, Yujia Li, Zhida Qian (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11651619.txt.
Description
An inflamed colon loses its rhythm, and Chen Lu and co-authors trace the failure to a quiet support cell in a 2024 mouse study. Beyond the muscle cells that squeeze the gut, the colon wall holds PDGFRα-positive cells whose SK3 channels let potassium out and relax the muscle. In colitis those brakes matter.
Mice given a colitis-inducing chemical lost weight, their colons shortened, and the traveling waves of contraction that move contents along fell into disorder. The support cells and their channels were dialed down in the sick animals. Drugs that block or boost the SK3 channel also moved the sick colon less than the healthy one, showing the pathway's grip had loosened. The authors pin a share of colitis's transit trouble on this silenced relaxation circuit.
Catalog record
| CREATOR | Chen Lu, Hongxia Zhu, Haiqian Lu, Xianjing Xie, Ling Tong, Yujia Li, Zhida Qian |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |