Causal relationship between immune cells and periodontitis: A Mendelian randomization study
Junlei Bi, Yuxin Chen, Jie Zhang, Jiaqi Yan, Aiyun Ge, Wenhao Ye, Changqing Liu, Hebao Wen, Caiyun Ma · 2024
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Description
Junlei Bi and eight co-authors use genetics to test whether immune cell types cause gum disease, in this 2024 study. Periodontitis, chronic gum inflammation, destroys the tissue holding teeth. Immune cells are deeply involved, but correlation cannot say which cell types drive the disease and which merely react.
Mendelian randomization borrows genetic variants as natural experiments. The team scanned 731 immune cell subtypes against gum disease data. Several statistical methods guarded against side effects. Significant causal signals emerged for B cells, T-cell maturation stages, and regulatory T cells. Two receptors on myeloid cells, TREM-1 and TREM-2, showed intricate patterns worth deeper study. The authors say the results map causal immune contributors to gum disease, offering targets for prevention research and a base for probing wider body-wide effects.
Catalog record
| CREATOR | Junlei Bi, Yuxin Chen, Jie Zhang, Jiaqi Yan, Aiyun Ge, Wenhao Ye, Changqing Liu, Hebao Wen, Caiyun Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |