Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction
Maddalena Ardissino, Elvezia Maria Paraboschi, Samuel A. Lambert, Lois G. Kim, Martin Kelemen, Giuseppe Maglietta, Antonio Crocamo, Giulia Magnani, Serena Bricoli, Luigi Vignali, Giampaolo Niccoli, Marco Tubaro, Libor Pastika, Arunashis Sau, Fu Siong Ng, Antonio de Marvao, Michael C. Honigberg, Prad · 2024
Read Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction by Maddalena Ardissino, Elvezia Maria Paraboschi, Samuel A. Lambert, Lois G. Kim, Martin Kelemen, Giuseppe Maglietta, Antonio Crocamo, Giulia Magnani, Serena Bricoli, Luigi Vignali, Giampaolo Niccoli, Marco Tubaro, Libor Pastika, Arunashis Sau, Fu Siong Ng, Antonio de Marvao, Michael C. Honigberg, Prad (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11651354.txt.
Description
Maddalena Ardissino and a large team asked whether genes can flag who will have a second heart event after an early heart attack, in a 2024 study. The cohort came from an Italian study of people whose first attack struck before age forty five. The team built a polygenic score from many small gene effects and also checked for single gene faults.
Over about twenty years of follow up, half the patients had a new event such as a second attack, a stroke, or death. Each step up in the gene score raised the risk by about a fifth. The score beat most single risk factors, though adding it to standard factors lifted the full model only a small amount.
Catalog record
| CREATOR | Maddalena Ardissino, Elvezia Maria Paraboschi, Samuel A. Lambert, Lois G. Kim, Martin Kelemen, Giuseppe Maglietta, Antonio Crocamo, Giulia Magnani, Serena Bricoli, Luigi Vignali, Giampaolo Niccoli, Marco Tubaro, Libor Pastika, Arunashis Sau, Fu Siong Ng, Antonio de Marvao, Michael C. Honigberg, Prad |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |