Effective, but Safe? Physiologically Based Pharmacokinetic (PBPK)-Modeling-Based Dosing Study of Molnupiravir for Risk Assessment in Pediatric Subpopulations
Sarang Mishra, Katharina Rox · 2024
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Description
Sarang Mishra and Katharina Rox model safe doses of an antiviral drug for children using body simulation. Their twenty twenty-four paper covers molnupiravir, an oral drug active against several viruses. Only one intravenous drug was approved for at-risk children after the COVID pandemic, leaving a gap.
High doses hurt bone and cartilage growth in young rats, a worry for the youngest patients. The team built a physiologically based model from adult data, then scaled it to newborns, infants, and young children. That lets them test doses that may work yet stay under the harm line. Viruses like Ebola, with no treatment and high death rates, drive the need.
Catalog record
| CREATOR | Sarang Mishra, Katharina Rox |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |