Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury
Yongjing Guo, Huimin Chen, Jian Sun, Jingxiao Zhang, Yongjie Yin · 2024
Read Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury by Yongjing Guo, Huimin Chen, Jian Sun, Jingxiao Zhang, Yongjie Yin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11651138.txt.
Description
A pro-resolving lipid shields the liver in sepsis by blocking a cell death pathway, Yongjing Guo and co-authors show in a 2024 study. The mediator, maresin 1, calms inflammation and promotes tissue repair. Sepsis-induced acute liver injury has few targeted treatments. The team asked whether the mediator protects the liver by inhibiting ferroptosis, an iron-driven death program, through a known antioxidant pathway involving three named proteins.
A mouse sepsis model was created by cecal ligation and puncture. Cell experiments paired liver cells with macrophages under bacterial toxin stimulation. The mediator was given with and without a pathway inhibitor, and gene knockdown tested the pathway's necessity. Liver damage was scored by staining, and lipid peroxidation was measured. The pathway named in the title carried the protection.
Catalog record
| CREATOR | Yongjing Guo, Huimin Chen, Jian Sun, Jingxiao Zhang, Yongjie Yin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |