Definitions matter: Multicenter investigation of incidence and outcome of poor graft function after hematopoietic cell transplantation
Konradin F Müskens, Winny N R Collot‐d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A de Witte, Marc Bierings, Caroline A Lindemans, Stefan Nierkens, Mirjam E Belderbos · 2024
Read Definitions matter: Multicenter investigation of incidence and outcome of poor graft function after hematopoietic cell transplantation by Konradin F Müskens, Winny N R Collot‐d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A de Witte, Marc Bierings, Caroline A Lindemans, Stefan Nierkens, Mirjam E Belderbos (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11650888.txt.
Description
Konradin Muskens and co-authors show that the very definition of poor graft function after stem cell transplant bends reported rates. Their 2024 study pools more than thirty-five thousand blood counts from over eight hundred child and adult recipients at many centers. Three common definitions are run side by side on the same data.
Two-year rates swing wide by definition, from about seven to twenty percent in children, and five to eighteen percent in adults. Death rates for the group swing too. Patients caught only by loose definitions fare like those with good grafts, which hints they may not be ill at all. Shared, number-based thresholds are urged for studies and registries alike.
Catalog record
| CREATOR | Konradin F Müskens, Winny N R Collot‐d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A de Witte, Marc Bierings, Caroline A Lindemans, Stefan Nierkens, Mirjam E Belderbos |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |