Intramolecular C–H arylation of pyridine derivatives with a palladium catalyst for the synthesis of multiply fused heteroaromatic compounds
Yuki Nakanishi, Shoichi Sugita, Kentaro Okano, Atsunori Mori, Ian Baxendale · 2024
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Description
Yuki Nakanishi and co-authors fuse ring systems with a palladium catalyst in a 2024 study. Building multiply fused heteroaromatic compounds matters for drugs and materials, and direct carbon-hydrogen links promise shorter routes. Their test case joins a brominated amide to its own pyridine ring.
With a palladium salt at high heat, the ring closed in modest yield. Adding a phosphine ligand more than doubled the yield to near total. Cousin amides from several pyridine acids closed in good yields too. Even non-pyridine amides gave fused products above eighty percent. The method widens the fused-ring toolbox.
Catalog record
| CREATOR | Yuki Nakanishi, Shoichi Sugita, Kentaro Okano, Atsunori Mori, Ian Baxendale |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |