Use and discontinuation of antipsychotic medication in 20 years following a first episode of schizophrenia: results from the OPUS trial
Helene Gjervig Hansen, Helene Speyer, Anne Emilie Stürup, Carsten Hjorthøj, Dost Öngür, Merete Nordentoft, Nikolai Albert · 2024
Read Use and discontinuation of antipsychotic medication in 20 years following a first episode of schizophrenia: results from the OPUS trial by Helene Gjervig Hansen, Helene Speyer, Anne Emilie Stürup, Carsten Hjorthøj, Dost Öngür, Merete Nordentoft, Nikolai Albert (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11650151.txt.
Description
Helene Gjervig Hansen and co-authors follow antipsychotic use for twenty years after a first schizophrenia episode in a 2024 Danish study. The OPUS trial began with 496 patients in the late nineteen-nineties. Short drug courses clearly help, but lifetime patterns were unmapped. The team rechecked patients four times over two decades and pulled prescription records for everyone.
Only 143 patients remained at the final check, a steep loss the authors state plainly. Of those, about a third were free of psychotic symptoms while off medication. That group also logged the fewest days on drugs across the twenty years. Hospital stays and work status rounded out the picture. The record tempers both drug enthusiasm and drug fear with real long-run data.
Catalog record
| CREATOR | Helene Gjervig Hansen, Helene Speyer, Anne Emilie Stürup, Carsten Hjorthøj, Dost Öngür, Merete Nordentoft, Nikolai Albert |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |