ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice
David Lau, Stephanie Tobin, Horia Pribiag, Shingo Nakajima, Alexandre Fisette, Dominique Matthys, Anna Kristyna Franco Flores, Marie-Line Peyot, S. R. Murthy Madiraju, Marc Prentki, David Stellwagen, Thierry Alquier, Stephanie Fulton · 2024
Read ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice by David Lau, Stephanie Tobin, Horia Pribiag, Shingo Nakajima, Alexandre Fisette, Dominique Matthys, Anna Kristyna Franco Flores, Marie-Line Peyot, S. R. Murthy Madiraju, Marc Prentki, David Stellwagen, Thierry Alquier, Stephanie Fulton (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11649924.txt.
Description
David Lau and a large team find that one brain enzyme in a reward hub guards mice against diet-driven obesity, in a 2024 study. The enzyme, ABHD6, breaks down a cannabis-like signal molecule, so removing it should raise that signal and, by the usual logic, boost appetite. The team removed the enzyme in separate spots of the reward circuit using viral tools. The circuit runs from the ventral tegmental area to the nucleus accumbens and drives motivated behavior.
Against expectation, removing the enzyme in the accumbens, on the receiving side only, fully blocked diet-induced obesity in male mice. Treated mice also sought food and drugs less and moved more. The result redraws the map of how this pathway controls weight, and it flags a drug target worth a closer look.
Catalog record
| CREATOR | David Lau, Stephanie Tobin, Horia Pribiag, Shingo Nakajima, Alexandre Fisette, Dominique Matthys, Anna Kristyna Franco Flores, Marie-Line Peyot, S. R. Murthy Madiraju, Marc Prentki, David Stellwagen, Thierry Alquier, Stephanie Fulton |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |