CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ
Juan Tang, Donglin Yu, Jiaojiao Song, Junfei Li, Yijuan Zhang, Xiangrui Ma, Wenlong Wang · 2024
Read CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ by Juan Tang, Donglin Yu, Jiaojiao Song, Junfei Li, Yijuan Zhang, Xiangrui Ma, Wenlong Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11649647.txt.
Description
Juan Tang and co-authors trace a chain of molecular switches that helps head and neck cancer grow. This cancer type, mostly squamous cell carcinoma, is common and deadly. At the chain's end sits a signaling protein called 14-3-3 zeta, long tied to tumor advance. The team sequenced tumor and healthy tissue from five patients to find circular RNAs that control it.
One circle, CircRNA_036186, stood out. It works by soaking up a small RNA, miR-193b-5p, that would otherwise hold the 14-3-3 zeta gene down. With the sponge in place, the protein's levels rise and the cancer's program runs freer. The authors propose the circle as both a biomarker and a drug target, and as a foothold for deeper study of circular RNA in this cancer.
Catalog record
| CREATOR | Juan Tang, Donglin Yu, Jiaojiao Song, Junfei Li, Yijuan Zhang, Xiangrui Ma, Wenlong Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |