Cancer-associated fibroblasts: heterogeneity, tumorigenicity and therapeutic targets
Keke Lv, Tianlin He · 2024
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Description
Keke Lv and Tianlin He review cancer-associated fibroblasts in this 2024 paper. Cancer is marked by immune evasion, active metabolism, and fast growth. Most research has focused on the cancer cells themselves, but the tissue around them also shapes the disease.
Fibroblasts tied to cancer are a main part of that surrounding tissue, called the tumor microenvironment. These cells change over time and can play two-sided roles. Their actions span the full course of the disease: tumor growth, spread, drug resistance, and patient outlook. The review lays out where these cells come from, what types exist, and what each type does. It also covers treatment ideas that target them. The authors argue that a clear map of this cell family could open new routes to therapy, since direct attacks on cancer cells have had limited broad success.
Catalog record
| CREATOR | Keke Lv, Tianlin He |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |