Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts
Yangpeng Li, Zhu Liu, Christopher O'Shea, Jianhong Li, Xian Luo, Tangting Chen, Xianhong Ou, Weichao Liu, Guoliang Hao, Christopher L.-H. Huang, Davor Pavlovic, Xiaoqiu Tan, Ming Lei · 2024
Read Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts by Yangpeng Li, Zhu Liu, Christopher O'Shea, Jianhong Li, Xian Luo, Tangting Chen, Xianhong Ou, Weichao Liu, Guoliang Hao, Christopher L.-H. Huang, Davor Pavlovic, Xiaoqiu Tan, Ming Lei (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11649530.txt.
Description
Yangpeng Li and co-authors published a 2024 study filming voltage and calcium inside mouse hearts carrying a dangerous mutation. The mutation, in a channel called RyR2, causes a syndrome where stress or excitement triggers lethal heart rhythms. Abnormal calcium release from storage is the suspected trigger, but how it varies across the intact heart was murky.
The team mapped both signals at once, optically, in whole hearts from normal mice and mutation carriers. They recorded before and during a dose of a stimulating drug that mimics stress. Watching voltage and calcium together, region by region, reveals where the two fall out of step. Those mismatches are candidate birthplaces for the rogue rhythms. The study works in a living system rather than isolated cells, keeping the heart's geography intact. Its maps aim to explain a sudden-death syndrome at the level where it actually strikes.
Catalog record
| CREATOR | Yangpeng Li, Zhu Liu, Christopher O'Shea, Jianhong Li, Xian Luo, Tangting Chen, Xianhong Ou, Weichao Liu, Guoliang Hao, Christopher L.-H. Huang, Davor Pavlovic, Xiaoqiu Tan, Ming Lei |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |