Swine IFN cocktail can reduce mortality and lessen the tissue injury caused by African swine-fever-virus-infected piglets
Yitong Jiang, Fei Jiang, Wenzhu Zhai, Ying Huang, Zhongbao Pang, Chunhao Tao, Zhen Wang, Yuheng He, Yuanyuan Chu, Hongfei Zhu, Jiajun Wu, Hong Jia · 2024
Read Swine IFN cocktail can reduce mortality and lessen the tissue injury caused by African swine-fever-virus-infected piglets by Yitong Jiang, Fei Jiang, Wenzhu Zhai, Ying Huang, Zhongbao Pang, Chunhao Tao, Zhen Wang, Yuheng He, Yuanyuan Chu, Hongfei Zhu, Jiajun Wu, Hong Jia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11649406.txt.
Description
Yitong Jiang and co-authors test a mix of immune proteins to guard piglets against African swine fever in 2024. The viral disease is deadly and threatens pig farms round the world. No vaccine is on sale for it. The team fused three swine immune proteins with an antibody part. The fusions were made in lab cells.
Tests showed the fusions fought a test virus in two cell systems. They switched on a set of defense genes in pig cells. Piglets given the mix before infection had lower virus loads. Death came later, and tissue harm was less than in untreated piglets. The authors see the mix as a path to prevent and treat the disease.
Catalog record
| CREATOR | Yitong Jiang, Fei Jiang, Wenzhu Zhai, Ying Huang, Zhongbao Pang, Chunhao Tao, Zhen Wang, Yuheng He, Yuanyuan Chu, Hongfei Zhu, Jiajun Wu, Hong Jia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |