Klebsiella pneumoniae capsular polysaccharide: Mechanism in regulation of synthesis, virulence, and pathogenicity
Li Xu, Jiayang Li, Wenqi Wu, Xiuwen Wu, Jianan Ren · 2024
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Description
Xu, Li, Wu, Wu, and Ren review the capsule of a pneumonia bacterium and how it drives virulence, in a review from twenty twenty-four. Hypervirulent strains cause severe invasive disease yet once yielded to antibiotics. Resistant hypervirulent strains now spread worldwide, raising urgent concern. The sugary capsule is a chief weapon behind that virulence.
Capsule makeup varies widely and shapes how deadly a strain is. The review covers capsule structure, typing, and the genes that build and regulate it. It details how the capsule evades immunity and aids spread in the body. Since capsule-targeted therapies show promise, sharper structural knowledge guides drug design. The synthesis serves as a reference for pathogenesis research.
Catalog record
| CREATOR | Li Xu, Jiayang Li, Wenqi Wu, Xiuwen Wu, Jianan Ren |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |