Dynamics and mechanism of DNA repair by a bifunctional cryptochrome
Luyao Yan, Xiaodan Cao, Lijuan Wang, Jie Chen, Aziz Sancar, Dongping Zhong · 2024
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Description
Luyao Yan and colleagues watched a DNA repair protein at work in 2024. Light-activated proteins can repair ultraviolet damage. A related protein family sends light signals instead. One algae protein does both jobs. Ultrafast spectroscopy tracked its repair steps.
Site-directed mutations tested key protein parts. Two histidine residues proved essential for repair. Removing them nearly stopped repair completely. Electron and proton moves were coupled tightly. The full repair cycle is described. The active flavin form was identified. Findings work at molecular detail level. Dual-function proteins are now clearer. Blue light switches the protein on.
Catalog record
| CREATOR | Luyao Yan, Xiaodan Cao, Lijuan Wang, Jie Chen, Aziz Sancar, Dongping Zhong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |