Distinct therapeutic effects of auraptene and umbelliprenin on TNF-α and IL-17 levels in a murine model of chronic inflammation
Saeid Joveini, Fatemeh Yarmohammadi, Mehrdad Iranshahi, Amin Reza Nikpoor, Vahid Reza Askari, Armin Attaranzadeh, Leila Etemad, Zhila Taherzadeh · 2024
Read Distinct therapeutic effects of auraptene and umbelliprenin on TNF-α and IL-17 levels in a murine model of chronic inflammation by Saeid Joveini, Fatemeh Yarmohammadi, Mehrdad Iranshahi, Amin Reza Nikpoor, Vahid Reza Askari, Armin Attaranzadeh, Leila Etemad, Zhila Taherzadeh (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11648749.txt.
Description
Saeid Joveini and co-authors compare two plant compounds against chronic inflammation in rats in this 2024 study. Both compounds come from plants of the carrot family. Inflammation signals named in the title are the readouts of interest. Sixty male rats were split into ten groups. Once lasting inflammation was confirmed, treated groups got one compound by mouth for nine days. Tissue samples were examined after the course ended.
Body weight changes were tracked as a health sign. One compound at a set dose raised weight gain clearly. Blood levels of the two signal proteins showed distinct patterns per compound. The pair are not interchangeable, the results suggest. Such differences matter for picking a lead compound for arthritis research. The study is an animal experiment, not a human trial. Doses and effects are fully tabled in the article.
Catalog record
| CREATOR | Saeid Joveini, Fatemeh Yarmohammadi, Mehrdad Iranshahi, Amin Reza Nikpoor, Vahid Reza Askari, Armin Attaranzadeh, Leila Etemad, Zhila Taherzadeh |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |