RAD51 plays critical roles in DNMT1-mediated maintenance methylation of genomic DNA by dually regulating the ubiquitin ligase UHRF1
Guangxue Liu, Kaiyan Huang, Shiyao Liu, Yali Xie, Jinyan Huang, Tingbo Liang, Pumin Zhang · 2024
Read RAD51 plays critical roles in DNMT1-mediated maintenance methylation of genomic DNA by dually regulating the ubiquitin ligase UHRF1 by Guangxue Liu, Kaiyan Huang, Shiyao Liu, Yali Xie, Jinyan Huang, Tingbo Liang, Pumin Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11648659.txt.
Description
Liu and co-authors report a study, published in 2024, on a DNA repair protein with a surprise second job. The protein is famous for fixing broken DNA by matching it to a healthy copy. The team found it also guards the chemical tags that mark DNA for long-term silencing. Those tags must be copied faithfully each time a cell divides, or gene control unravels. The protein steers a partner that does the copying, in two opposing ways at once.
On one hand, it reins in a tagging enzyme that would otherwise mark the copier for destruction. On the other, it helps that enzyme place a needed mark on the DNA's packing spools. Removing the repair protein broke both balances and drained the cell's DNA tags. The dual role links DNA repair to the upkeep of gene silencing.
Catalog record
| CREATOR | Guangxue Liu, Kaiyan Huang, Shiyao Liu, Yali Xie, Jinyan Huang, Tingbo Liang, Pumin Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |