TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain
Yumi Matsushita, Kaede Yoshida, Miyuki Yoshiya, Takahiro Shimizu, Satoshi Tsukamoto, Nobuki Kudo, Yuichi Takeuchi, Makoto Higuchi, Masafumi Shimojo · 2024
Read TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain by Yumi Matsushita, Kaede Yoshida, Miyuki Yoshiya, Takahiro Shimizu, Satoshi Tsukamoto, Nobuki Kudo, Yuichi Takeuchi, Makoto Higuchi, Masafumi Shimojo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11648612.txt.
Description
Yumi Matsushita and co-authors pinpoint a cell channel that lets ultrasound stir brain cells, a method that can reach deep brain targets without surgery. How sound waves switch neurons on was largely unknown. Their 2024 study works with mouse brain cells in dishes and in living mice.
Ultrasound triggered fast calcium surges in the cultured cells. Blocking firing or cell-to-cell signaling shrank the responses. The key test: blocking or removing one force-sensing channel, TRPC6, nearly wiped the responses out. Giving mice a blocker for that channel also cut firing in the cortex under skull ultrasound. The authors call the channel indispensable for this effect in the mammalian brain.
Catalog record
| CREATOR | Yumi Matsushita, Kaede Yoshida, Miyuki Yoshiya, Takahiro Shimizu, Satoshi Tsukamoto, Nobuki Kudo, Yuichi Takeuchi, Makoto Higuchi, Masafumi Shimojo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |