Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M Halliday, Nicolas Dzamko · 2024
Read Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model by Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M Halliday, Nicolas Dzamko (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11648304.txt.
Description
Parkinson's disease kills dopamine neurons in the midbrain while a protein, alpha-synuclein, piles up in bad forms. Weiss and co-authors grow a human midbrain model from stem cells, neurons and astrocytes together, from both patients and healthy donors. They switch on an immune sensor called TLR2 and seed the bad protein, then watch each cell type.
The sensor's activation jammed the cells' waste clearance and grew the protein deposits in both neurons and astrocytes, and the dopamine neurons died back. Astrocytes turned toxic in profile, and their change tracked the neuron loss. The authors argue astrocyte failure is part of how this immune path drives the disease.
Catalog record
| CREATOR | Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M Halliday, Nicolas Dzamko |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |