TRF‐16 Inhibits Lung Cancer Progression by Hindering the N6‐Methyladenosine Modification of CPT1A mRNA
Jiankui Ye, Yu Chen, Zhuowei Shao, Yili Wu, You Li, Shuai Fang, Shibo Wu · 2024
Read TRF‐16 Inhibits Lung Cancer Progression by Hindering the N6‐Methyladenosine Modification of CPT1A mRNA by Jiankui Ye, Yu Chen, Zhuowei Shao, Yili Wu, You Li, Shuai Fang, Shibo Wu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647991.txt.
Description
Jiankui Ye and co-authors show a small RNA fragment that slows lung cancer by guarding a metabolic gene's message, in this 2024 paper. The fragment, tRF-16, is scarce in lung cancer cells. Restoring it in the lab curbed growth, movement, invasion, and even resistance to radiation. Tumor growth in animals also slowed. The team traced the effect to a fat-burning gene called CPT1A.
A helper protein normally grabs a chemical mark on that gene's message and keeps it stable. The fragment jams that grip, so the message decays faster and fat metabolism stalls. Starved of that fuel route, the cancer cells lose steam. The authors present tRF-16 as both a brake on lung cancer and a possible handle for future therapy design.
Catalog record
| CREATOR | Jiankui Ye, Yu Chen, Zhuowei Shao, Yili Wu, You Li, Shuai Fang, Shibo Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |