Detection of genome instability by 53BP1 expression as a long-lasting health effect in human epidermis surrounding radiation-induced skin cancers
Katsuya Matsuda, Hirokazu Kurohama, Yutaka Kuwatsuka, Akira Iwanaga, Hiroyuki Murota, Masahiro Nakashima · 2024
Read Detection of genome instability by 53BP1 expression as a long-lasting health effect in human epidermis surrounding radiation-induced skin cancers by Katsuya Matsuda, Hirokazu Kurohama, Yutaka Kuwatsuka, Akira Iwanaga, Hiroyuki Murota, Masahiro Nakashima (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647933.txt.
Description
Katsuya Matsuda and five co-authors studied skin tissue from people with radiation-linked skin cancers in this two thousand twenty-four paper. Earlier work in Nagasaki atomic bomb survivors hinted that DNA damage responses stay switched on in the skin around tumors for decades.
The team stained tissue samples for a protein called 53BP1, which marks sites where the cell is responding to DNA damage, alongside other markers. They found scattered activation of this response in skin exposed to medical radiation or ultraviolet light, even outside the tumors themselves. Abnormal 53BP1 patterns were even more common inside cancer cells. The study supports the idea that long-lasting genome instability in exposed skin helps set the stage for later cancers.
Catalog record
| CREATOR | Katsuya Matsuda, Hirokazu Kurohama, Yutaka Kuwatsuka, Akira Iwanaga, Hiroyuki Murota, Masahiro Nakashima |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |