Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems
Yasuo Miura, Sumie Fujii, Tatsuo Ichinohe · 2024
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Description
Yasuo Miura, Sumie Fujii, and Tatsuo Ichinohe review stem cell therapies for acute radiation syndrome, in a paper from 2024. A high dose of radiation can wreck the gut, marrow, skin, and lungs. The immune system then fails, and infection can kill. Mesenchymal stem cells can calm swelling, tune immunity, and aid tissue repair.
Such cells are already used in Japan for some transplant and bowel conditions. Trials in animals with radiation harm look hopeful, but proof in people is thin. The review turns to the tiny vesicles these cells shed, which carry proteins and RNA that do much of the work. Vesicle therapy could dodge some risks of live cells. Open questions remain, such as whether vesicles wake the body's own stem cells. The authors map what must be settled before clinic use.
Catalog record
| CREATOR | Yasuo Miura, Sumie Fujii, Tatsuo Ichinohe |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |