A novel in-silico approach to design a multiepitope peptide as a vaccine candidate for Aeromonashydrophila
Mahdieh SobhZahedi, Mohammad Hossein YektaKooshali · 2024
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Description
Mahdieh SobhZahedi and Mohammad Hossein YektaKooshali design a vaccine candidate on the computer in a 2024 paper on Aeromonas hydrophila. This rod-shaped bacterium lives in freshwater and sewage, infects fish and people, and has grown resistant to many antibiotics, yet no commercial vaccine works well against it.
Working in silico, the authors pulled the bacterial genome, listed its open reading frames, and screened them for toxicity, allergenicity, immune strength, and similarity to host proteins. From the survivors they assembled a multiepitope peptide, a single construct carrying several immune targets at once. The design offers a candidate for lab testing against a hard-to-treat pathogen.
Catalog record
| CREATOR | Mahdieh SobhZahedi, Mohammad Hossein YektaKooshali |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |