FAPs orchestrate homeostasis of muscle physiology and pathophysiology
Kai Yin, Chengmin Zhang, Zihan Deng, Xiaoyu Wei, Tingwen Xiang, Chuan Yang, Can Chen, Yueqi Chen, Fei Luo · 2024
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Description
Muscle weakness in many diseases comes with swelling, lost fibers, fat creeping in, and scarring. Kai Yin led a team that reviews the muscle's inner neighborhood and the cells that keep it in balance. At the center sit FAPs, flexible starter cells that never become muscle themselves. Instead they can turn into fat, bone, cartilage, or scar-forming cells, build the tissue scaffold, aid repair, and tend the nerve-muscle link.
When injury or disease upsets the neighborhood, these same cells misbehave and drive the damage patterns doctors see. The review maps the signals that steer the cells, for good or ill. It picks out drug targets on those paths that might restore balance and help muscle heal.
Catalog record
| CREATOR | Kai Yin, Chengmin Zhang, Zihan Deng, Xiaoyu Wei, Tingwen Xiang, Chuan Yang, Can Chen, Yueqi Chen, Fei Luo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |