Balancing CIK Cell Cancer Immunotherapy and PPAR Ligands: One Potential Therapeutic Application for CNS Malignancies
Kira Vordermark, JingJing Pu, Amit Sharma, Jarek Maciacyzk, Ingo G H Schmidt‐Wolf · 2024
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Description
Vordermark and four co-authors paired cell therapy with a receptor blocker in this study from twenty twenty-four. Cytokine-induced killer cells have shown promise against glioblastoma in trials. A separate drug, GW-9662, blocks the PPAR gamma receptor found in brain tissue. The team tested both on neuroblastoma and glioblastoma cell lines.
The blocker alone slowed tumor cell growth in both lines. It lowered a methylation enzyme's expression while barely touching a growth signaling pathway. Global methylation marks shifted partly as well. Adding the killer cells on top raised tumor cell killing significantly. The authors present the pairing as a candidate strategy for malignant brain tumors. They stress the evidence is early and from cell cultures.
Catalog record
| CREATOR | Kira Vordermark, JingJing Pu, Amit Sharma, Jarek Maciacyzk, Ingo G H Schmidt‐Wolf |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |