Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma
Xiaokai Zhang, Xiujiao Deng, Jizhou Tan, Haikuan Liu, Hong Zhang, Chengzhi Li, Qingjun Li, Jinxue Zhou, Zeyu Xiao, Jiaping Li · 2024
Read Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma by Xiaokai Zhang, Xiujiao Deng, Jizhou Tan, Haikuan Liu, Hong Zhang, Chengzhi Li, Qingjun Li, Jinxue Zhou, Zeyu Xiao, Jiaping Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647502.txt.
Description
Xiaokai Zhang and co-authors built in 2024 a melt-away gel that carries a chemotherapy drug into liver tumors through their blood supply. The standard blocking treatment can starve vessels for good and stir up low oxygen, which dulls the immune response. Their gel mixes a temperature-sensitive base with iron oxide particles and the drug idarubicin.
In rats with liver tumors grown in place, the gel blocked vessels well and shrank disease. It also triggered a form of tumor cell death that alerts the immune system. Pairing that effect with an immune checkpoint drug looked promising in their tests. The authors say a degradable blocker can do double duty: deliver the drug and wake immunity. The work aims at better options for a deadly cancer.
Catalog record
| CREATOR | Xiaokai Zhang, Xiujiao Deng, Jizhou Tan, Haikuan Liu, Hong Zhang, Chengzhi Li, Qingjun Li, Jinxue Zhou, Zeyu Xiao, Jiaping Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |