An automated blood test for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) to predict the absence of intracranial lesions on head CT in adult patients with mild traumatic brain injury: BRAINI, a multicentre observational study in Europe
Alfonso Lagares, Javier de la Cruz, Hugo Terrisse, Odile Mejan, Vladislav Pavlov, Celine Vermorel, Jean-François Payen, of the BRAINI participants and investigators · 2024
Read An automated blood test for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) to predict the absence of intracranial lesions on head CT in adult patients with mild traumatic brain injury: BRAINI, a multicentre observational study in Europe by Alfonso Lagares, Javier de la Cruz, Hugo Terrisse, Odile Mejan, Vladislav Pavlov, Celine Vermorel, Jean-François Payen, of the BRAINI participants and investigators (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647500.txt.
Description
Alfonso Lagares and co-authors validate a blood test that can spare head-injury patients a CT scan, in this 2024 study. After a mild brain injury, two proteins leak into the blood when the brain is harmed. A fast automated test measures both, and the team checked set cutoffs across sixteen emergency departments in France and Spain.
Among more than fourteen hundred patients, the test caught nearly every scan-proven injury and cleared the great majority of uninjured patients. A rival blood marker performed worse. Higher protein levels also tracked with slower recovery at three months.
Catalog record
| CREATOR | Alfonso Lagares, Javier de la Cruz, Hugo Terrisse, Odile Mejan, Vladislav Pavlov, Celine Vermorel, Jean-François Payen, of the BRAINI participants and investigators |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |