Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variants
Lok Bahadur Shrestha, Katie Tungatt, Anupriya Aggarwal, Aija Stubis, Nicole L. Fewings, Christina Fichter, Anouschka Akerman, Chaturaka Rodrigo, Nicodemus Tedla, Sharon Lee, Andrew R. Lloyd, Fabienne Brilot, Warwick J. Britton, Anthony Kelleher, Ian D. Caterson, Mark W. Douglas, Rebecca Rockett, Stu · 2024
Read Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variants by Lok Bahadur Shrestha, Katie Tungatt, Anupriya Aggarwal, Aija Stubis, Nicole L. Fewings, Christina Fichter, Anouschka Akerman, Chaturaka Rodrigo, Nicodemus Tedla, Sharon Lee, Andrew R. Lloyd, Fabienne Brilot, Warwick J. Britton, Anthony Kelleher, Ian D. Caterson, Mark W. Douglas, Rebecca Rockett, Stu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647467.txt.
Description
Lok Shrestha and co-authors compare two COVID booster styles head to head. One shot held only the original strain, the other added an Omicron variant. Blood drawn a month later showed both raised neutralizing antibodies against five variants, even one that had not yet appeared when samples were taken.
The two strain shot lifted antibodies against the Omicron branch more strongly. It also grew a broader pool of memory B cells, the reserves that answer future infections. That breadth tracked with the antibody breadth. T cell boosts mostly matched, with the two strain shot ahead on one variant. The authors credit the wider B cell pool for the edge.
Catalog record
| CREATOR | Lok Bahadur Shrestha, Katie Tungatt, Anupriya Aggarwal, Aija Stubis, Nicole L. Fewings, Christina Fichter, Anouschka Akerman, Chaturaka Rodrigo, Nicodemus Tedla, Sharon Lee, Andrew R. Lloyd, Fabienne Brilot, Warwick J. Britton, Anthony Kelleher, Ian D. Caterson, Mark W. Douglas, Rebecca Rockett, Stu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |