Different doses of epidural morphine combined with multimodal analgesia strategies for postpartum pain management: study protocol for a single-centre, double-blind randomised, pragmatic clinical trial

Description

Rou Yu and Xuemei Lin published the protocol for a trial seeking the best epidural morphine dose after cesarean delivery. Spinal morphine is the gold standard for post-cesarean pain, but newer multimodal strategies, mixing regional blocks and patient-controlled analgesia, aim to cut opioid side effects and monitoring burdens. The single-center, double-blind randomized trial plans to enroll 310 healthy women scheduled for cesarean under combined spinal-epidural anesthesia. Different morphine doses will be layered onto multimodal regimens.

Recruitment was planned at a Sichuan university hospital across twenty twenty-four. Publishing the protocol in advance locks the design, outcomes, and analysis plan against later drift. Pain after cesarean competes with a newborn's needs: mothers must move, feed, and bond. Finding the lowest morphine dose that still controls moderate-to-severe pain would ease both recovery and the respiratory monitoring such doses demand.

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Source: https://europepmc.org/articles/PMC11647343