FGF20 promotes spinal cord injury repair by inhibiting the formation of necrotic corpuscle P‐MLKL/P‐RIP1/P‐RIP3 in neurons
Xiong Cai, Zhenwen Xie, Juan Zhao, Wenjie Lu, Zhongwei Zhu, Min Chen, Zhiyang Huang, Yibo Ying, Yining Fu, Jiake Xu, Sipin Zhu · 2024
Read FGF20 promotes spinal cord injury repair by inhibiting the formation of necrotic corpuscle P‐MLKL/P‐RIP1/P‐RIP3 in neurons by Xiong Cai, Zhenwen Xie, Juan Zhao, Wenjie Lu, Zhongwei Zhu, Min Chen, Zhiyang Huang, Yibo Ying, Yining Fu, Jiake Xu, Sipin Zhu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647335.txt.
Description
After a spinal cord injury, many nerve cells die by a runaway process called necroptosis, and that loss blocks recovery. Xiong Cai and co-authors tested in 2024 whether a growth factor named FGF20 could protect those cells in mice. The factor supports nerve growth in healthy development, so the team gave its human form to injured mice.
Treated mice moved better on standard tests and kept more living neurons at the injury site. Signs of new nerve growth rose, and the scar that walls off the injury formed more slowly. Measures of necroptosis fell as well, matching the survival gains. The authors propose FGF20 as a candidate treatment worth carrying forward.
Catalog record
| CREATOR | Xiong Cai, Zhenwen Xie, Juan Zhao, Wenjie Lu, Zhongwei Zhu, Min Chen, Zhiyang Huang, Yibo Ying, Yining Fu, Jiake Xu, Sipin Zhu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |