miR-149-3p targeting TMPRSS4 regulates the sensitivity to cisplatin to inhibit the progression of lung cancer
Beibei Qin, Dongfang Tang, Mingzhi Zhang · 2025
Read miR-149-3p targeting TMPRSS4 regulates the sensitivity to cisplatin to inhibit the progression of lung cancer by Beibei Qin, Dongfang Tang, Mingzhi Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647265.txt.
Description
Beibei Qin, Dongfang Tang, and Mingzhi Zhang studied a small RNA in two thousand twenty-five that may make lung cancer respond better to a key drug. Lung cancer cells often grow resistant to cisplatin during treatment. The RNA, miR-149-3p, was low in cancer tissue, while its target gene, TMPRSS4, was high.
Raising the RNA slowed cancer growth, pushed cells to die, and made them more sensitive to cisplatin. It did so by lowering TMPRSS4, a protein that helps cancer spread. In mice, high RNA levels also boosted drug response. The work points to a paired target for future lung cancer care.
Catalog record
| CREATOR | Beibei Qin, Dongfang Tang, Mingzhi Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |