Cuproptosis-related gene ATOX1 promotes MAPK signaling and diffuse large B-cell lymphoma proliferation via modulating copper transport
Junjie Xie, Zhixiong Shao, Changjie Li, Cheng Zeng, Biao Xu · 2025
Read Cuproptosis-related gene ATOX1 promotes MAPK signaling and diffuse large B-cell lymphoma proliferation via modulating copper transport by Junjie Xie, Zhixiong Shao, Changjie Li, Cheng Zeng, Biao Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647247.txt.
Description
Junjie Xie and four co-authors study a copper handling gene in diffuse large B-cell lymphoma in this 2024 paper. The gene, ATOX1, helps move copper inside cells and ties to cuproptosis, a copper driven cell death. Data mining of lymphoma samples showed the gene switched on higher in tumors than in normal tissue. Lab tests then cut the gene down in lymphoma cells. Growth slowed, and cells stalled at one cell cycle checkpoint. A growth signaling pathway, MAPK, also dimmed when the gene fell.
Adding copper restored that pathway's activity, tying the effect to copper transport. A copper blocking drug killed lymphoma cells in a dose dependent way, and gene knockdown made it stronger. The authors read ATOX1 as a driver that keeps the MAPK pathway fed with copper. Blocking copper flow, they suggest, could be a route against this common lymphoma type.
Catalog record
| CREATOR | Junjie Xie, Zhixiong Shao, Changjie Li, Cheng Zeng, Biao Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |