Inhibitory maturation and ocular dominance plasticity in mouse visual cortex require astrocyte CB1 receptors
Rogier Min, Yi Qin, Sven Kerst, M Hadi Saiepour, Mariska van Lier, Christiaan N Levelt · 2024
Read Inhibitory maturation and ocular dominance plasticity in mouse visual cortex require astrocyte CB1 receptors by Rogier Min, Yi Qin, Sven Kerst, M Hadi Saiepour, Mariska van Lier, Christiaan N Levelt (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647246.txt.
Description
Min and co-authors show that receptors on star-shaped brain support cells, not neurons, drive a key step in visual brain wiring. Cannabinoid CB1 receptors shape how inhibitory circuits mature in the young visual cortex. They were long assumed to sit on neuron endings. The team removed the receptors from single cell types in mice. Removing them from astrocytes stalled the maturing of inhibitory transmission. It also cut the cortex's ability to shift eye dominance during the critical period.
Removing the same receptors from interneurons left both processes intact. The split pins the effect on astrocytes. The result reframes how cannabis-like signals guide early brain development.
Catalog record
| CREATOR | Rogier Min, Yi Qin, Sven Kerst, M Hadi Saiepour, Mariska van Lier, Christiaan N Levelt |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |