Knockdown of Methylation‐Related Gene MBD2 Blocks Cell Growth by Upregulating p21 Expression in Head and Neck Squamous Cell Carcinoma
Ting Cao, Xia Shen, Fei Pei, Taogeng Jiang, Jun Zhang, Hong Zhou · 2024
Read Knockdown of Methylation‐Related Gene MBD2 Blocks Cell Growth by Upregulating p21 Expression in Head and Neck Squamous Cell Carcinoma by Ting Cao, Xia Shen, Fei Pei, Taogeng Jiang, Jun Zhang, Hong Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647173.txt.
Description
Ting Cao and co-authors studied a gene reading protein in a cancer of the mouth and throat, in work published in 2024. The protein binds to marked DNA and silences genes, which can help tumors grow, but its role in this cancer was unclear.
Using large cancer databases, the team found the protein is often overproduced in these tumors, and high levels went with shorter survival. In lab cells, blocking the protein raised the level of a brake gene that slows cell growth. A drug that strips DNA marks did the same, and the two together added up. Both steps slowed the cancer cells' growth and survival in the dish.
Catalog record
| CREATOR | Ting Cao, Xia Shen, Fei Pei, Taogeng Jiang, Jun Zhang, Hong Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |