Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions
Najma Farahani, Mina Alimohammadi, Mehdi Raei, Noushin Nabavi, Amir Reza Aref, Kiavash Hushmandi, Salman Daneshi, Alireza Razzaghi, Afshin Taheriazam, Mehrdad Hashemi · 2024
Read Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions by Najma Farahani, Mina Alimohammadi, Mehdi Raei, Noushin Nabavi, Amir Reza Aref, Kiavash Hushmandi, Salman Daneshi, Alireza Razzaghi, Afshin Taheriazam, Mehrdad Hashemi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647052.txt.
Description
Farahani and nine co-authors reviewed cell stress in urological cancers in this paper from twenty twenty-four. The endoplasmic reticulum folds proteins and balances calcium inside cells. When misfolded proteins pile up, the organelle enters a stressed state. In bladder, prostate, and kidney cancers, that stress cuts both ways.
Stress signals can feed tumor survival through self-digestion, yet they more often push cancer cells toward death. Tumors also exploit the pathway to dodge immunity via tiny exported parcels. Three sensor proteins govern the response, and raising one death signal is a recurring theme. Plant chemicals that stoke the stress show tumor-suppressing promise. The authors map targets for new therapies.
Catalog record
| CREATOR | Najma Farahani, Mina Alimohammadi, Mehdi Raei, Noushin Nabavi, Amir Reza Aref, Kiavash Hushmandi, Salman Daneshi, Alireza Razzaghi, Afshin Taheriazam, Mehrdad Hashemi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |