Microfluidic impedance flow cytometer leveraging virtual constriction microchannel and its application in leukocyte differential
Minruihong Wang, Jie Zhang, Xiao Chen, Yimin Li, Xukun Huang, Junbo Wang, Yueying Li, Xiaoye Huo, Jian Chen · 2024
Read Microfluidic impedance flow cytometer leveraging virtual constriction microchannel and its application in leukocyte differential by Minruihong Wang, Jie Zhang, Xiao Chen, Yimin Li, Xukun Huang, Junbo Wang, Yueying Li, Xiaoye Huo, Jian Chen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11647040.txt.
Description
Minruihong Wang and colleagues published an engineering study in 2024 on a chip device that sorts blood cells. The device measures electrical signals as cells flow past electrodes. Clinicians use such counts to tell white blood cell types apart. Older designs traded speed against sensitivity because cells squeezed through narrow channels.
The new design replaces the physical squeeze with flowing fluids. A conductive sample stream is pinched by insulating sheath fluid. Cells never touch the channel walls, so flow stays fast. The sensing zone shrinks, which sharpens the signals. A neural network read the signals from leukemia cell lines. It sorted them with near-perfect accuracy. Real white cell types from donors sorted nearly as well.
Catalog record
| CREATOR | Minruihong Wang, Jie Zhang, Xiao Chen, Yimin Li, Xukun Huang, Junbo Wang, Yueying Li, Xiaoye Huo, Jian Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |