Genomic mosaicism in colorectal cancer and polyposis syndromes: a systematic review and meta-analysis
Francisco Cezar Aquino de Moraes, Nayara Rozalem Moretti, Vitor Kendi Tsuchiya Sano, Cristiane Wen Tsing Ngan, Rommel Mario Rodríguez Burbano · 2024
Read Genomic mosaicism in colorectal cancer and polyposis syndromes: a systematic review and meta-analysis by Francisco Cezar Aquino de Moraes, Nayara Rozalem Moretti, Vitor Kendi Tsuchiya Sano, Cristiane Wen Tsing Ngan, Rommel Mario Rodríguez Burbano (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646957.txt.
Description
Francisco Cezar Aquino de Moraes and co-authors pool studies of genetic mosaicism in bowel cancer in a 2024 review. Mosaicism means only some cells carry a gene change, adding hidden diversity to tumors and polyp syndromes. The team measured how common it is and where it matters.
They gathered 27 studies covering 2,272 patients. Of these, 108 patients showed somatic mosaicism, for an overall rate near nine percent. Mosaic changes in the APC gene were far more common than in other genes. Rates for two repair genes were also reported. The authors urge adding mosaic screening to routine genetic testing.
Catalog record
| CREATOR | Francisco Cezar Aquino de Moraes, Nayara Rozalem Moretti, Vitor Kendi Tsuchiya Sano, Cristiane Wen Tsing Ngan, Rommel Mario Rodríguez Burbano |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |